Anti-Cytomegalovirus pp65 [3A12] antibody (ab6503)

Overview

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPhosphate buffered saline
  • Concentration information loading...
  • PurityProtein A purified
  • Clonality Monoclonal
  • Clone number3A12
  • MyelomaNS1/1-Ag4-1
  • IsotypeIgG2a
  • Light chain typekappa
  • Research Areas

Applications

Our Abpromise guarantee covers the use of ab6503 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB 1/16000.
ICC/IF 1/3200.

Target

  • RelevanceCytomegalovirus is a member of the herpes virus group, which includes herpes simplex virus types 1 and 2, varicella zoster virus (which causes chicken pox), and Epstein Barr virus (which causes infectious mononucleosis). These viruses share a characteristic ability to remain dormant within the body over a long period. CMV viral genes are co-ordinately expressed in groups at various times after infection. Early viral proteins are expressed in the nucleus of infected cells within 3 to 24 hours of infection prior to the commencement of viral DNA replication. This is followed by expression of the early intermediate genes, which encode enzymes required for viral DNA replication. After 48 to 72 hours, a number of late viral antigens may be demonstrated in the nuclei and cytoplasm of infected cells. pp65 is a 65kD phosphorylated glycoprotein and is the most abundant of the late antigens.
  • Alternative names
    • 65 kDa lower matrix phosphoprotein antibody
    • 65 kDa matrix phosphoprotein antibody
    • 65 kDa phosphoprotein antibody
    • CMV 65 kDa lower matrix phosphoprotein antibody
    • CMV pp65 antibody
    • Cytomegalovirus 65 kDa lower matrix phosphoprotein antibody
    • Cytomegalovirus pp65 antibody
    • HHV 5 antibody
    • PP65 antibody
    • Tegument protein pp65 antibody
    • Tegument protein UL83 antibody
    • UL83 antibody
    see all

References for Anti-Cytomegalovirus pp65 [3A12] antibody (ab6503)

This product has been referenced in:
  • McFarlane S  et al. Early induction of autophagy in human fibroblasts after infection with human cytomegalovirus or herpes simplex virus 1. J Virol 85:4212-21 (2011). WB . Read more (PubMed: 21325419) »
  • Le VT  et al. The Cytomegaloviral Protein pUL138 Acts as Potentiator of Tumor Necrosis Factor (TNF) Receptor 1 Surface Density To Enhance ULb'-Encoded Modulation of TNF-a Signaling. J Virol 85:13260-70 (2011). WB . Read more (PubMed: 21976655) »

See all 3 Publications for this product

Product Wall

Thank you for your inquiry. As you may have seen already, we have a number of HCMV pp65 antibodies available in our catalog (such as ab6503, ab8250, ab31624, ab49214, ab53489). These were raised against the pp65 protein, however, unfortunately the ...

Read More

I put your question forward to the originator but they said that the epitope has not been characterised so they do not have the information. I am sorry we cannot be of help to you.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"