You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Products:Cell Biology >> Apoptosis >> Nucleus >> Other

Anti-HDAC1 antibody - ChIP Grade (ab1767)

CodeSizePriceAbpointsAvailability
    
Add to basket
 

  • -

  •   
  •   
  •   

  •  

  •  
  •  

  •  

  •  
Updating...

Reassurance, Refunds & Replacements

If your product does not perform as described on this datasheet, we will refund or replace your product...

Read our guarantee »

Overview

Product name

Anti-HDAC1 antibody - ChIP Grade
See all HDAC1 products (22) ...

Description

Rabbit polyclonal to HDAC1 - ChIP Grade

Tested applications

ICC/IF, ChIP, IP, WBmore details

Cross reactivity

Reacts with

Fruit fly (Drosophila melanogaster)

Immunogen

Synthetic peptide: C-SGSGTGSGAGAKGAKENNI, corresponding to amino acids 503-521 of Fruit fly (Drosophila melanogaster) HDAC1

C-SGSGTGSGAGAKGAKENNI

Run BLAST with BLAST the sequence with ExPASyRun BLAST with BLAST the sequence with NCBI

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

serum with 0.02% sodium azide

Purity

Whole antiserum

Primary antibody notes

The SIN3/RPD3 deacetylase complex is essential for G(2) phase cell cycle progression and regulation of SMRTER corepressor levels.

Clonality

Polyclonal

Isotype

IgG

Research areas

Epigenetics and Nuclear Signaling >> ChIP'ing antibodies >> ChIP'ing antibodies
Cardiovascular >> Heart >> Hypertrophy >> Other
Epigenetics and Nuclear Signaling >> Chromatin Modifying Enzymes >> Acetylation >> HDACs >> Class I
Stem Cells >> Signaling Pathways >> Wnt >> HDACs
Epigenetics and Nuclear Signaling >> Transcription >> Other factors
Epigenetics and Nuclear Signaling >> Chromatin Modifying Enzymes >> Acetylation
Cell Biology >> Apoptosis >> Nucleus >> Other

Applications

Show applications key

Our Abpromise guarantee covers the use of ab1767 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B.

Tissue specificity

Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.

Sequence similarities

Belongs to the histone deacetylase family. HD type 1 subfamily.

Post-translational
modifications

Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.
Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.
Ubiquitinated by CHFR, leading to its degradation by the proteasome.

Cellular localization

Nucleus.

Target information above from: UniProt accessionQ13547 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • DKFZp686H12203 antibody
  • GON 10 antibody
  • HD 1 antibody
  • HD1 antibody
  • HDAC 1 antibody
  • HDAC1 antibody
  • hdac1: histone deacetylase 1 antibody
  • HDAC1_HUMAN antibody
  • Histone deacetylase 1 (HD1) antibody
  • Histone deacetylase 1 antibody
  • Reduced potassium dependency yeast homolog like 1 antibody
  • reduced potassium dependency yeast homolog-like 1 antibody
  • RPD3 (reduced potassium dependency yeast homolog) like 1 antibody
  • RPD3 (reduced potassium dependency) antibody
  • RPD3 antibody
  • RPD3L1 antibody
see all

Database links

References for Anti-HDAC1 antibody - ChIP Grade (ab1767)

This product has been referenced in:

  • Su L  et al. Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics. Cancer Cell 21:333-47 (2012). WB.Read more (PubMed: 22439931) »
  • Fitzsimons HL & Scott MJ Genetic modulation of Rpd3 expression impairs long-term courtship memory in Drosophila. PLoS One 6:e29171 (2011). IHC (PFA fixed); Fruit fly (Drosophila melanogaster).Read more (PubMed: 22195015) »

See all 5 publications for this product

Publishing research using ab1767? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"