Overview

  • Product nameAnti-DACH2 antibody
    See all DACH2 primary antibodies
  • Description
    Rabbit polyclonal to DACH2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide derived from a region between amino acids 525-574 of human DACH2. (Note:the exact amino acid sequence is proprietary)

  • Positive control
    • Jurkat cell lysate, human liver.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab30909 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 µg/ml. Detects a band of approximately 65 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionTranscription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain.
  • Sequence similaritiesBelongs to the DACH/dachshund family.
  • DomainThe DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • DACH 2 antibody
    • Dach2 antibody
    • DACH2_HUMAN antibody
    • Dachshund 2 antibody
    • Dachshund homolog 2 (Drosophila) antibody
    • Dachshund homolog 2 antibody
    • Dachshund2 antibody
    • FLJ31391 antibody
    • HGNC:16814 antibody
    • MGC138545 antibody
    see all

Anti-DACH2 antibody images

References for Anti-DACH2 antibody (ab30909)

ab30909 has not yet been referenced specifically in any publications.

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