Overview

  • Product name
  • Description
    Rabbit polyclonal to Dact2
  • Tested applications
    Suitable for: WB, ELISA, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A 12 amino acid synthetic peptide from near the amino terminus of human Dact2 (NP_999627).

  • Positive control
    • SK N SH cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab79042 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 83 kDa.
ELISA Use at an assay dependent dilution.
ICC/IF Use a concentration of 20 µg/ml.

Target

  • Function
    Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors.
  • Sequence similarities
    Belongs to the dapper family.
  • Domain
    The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins.
  • Information by UniProt
  • Database links
  • Alternative names
    • bA503C24.7 antibody
    • C6orf116 antibody
    • Chromosome 6 open reading frame 116 antibody
    • Dact2 antibody
    • DACT2_HUMAN antibody
    • Dapper antagonist of beta catenin homolog 2 antibody
    • Dapper antagonist of beta catenin homolog 2 Xenopus laevis antibody
    • Dapper homolog 2 antagonist of beta catenin antibody
    • Dapper homolog 2 antagonist of beta catenin xenopus antibody
    • Dapper homolog 2 antibody
    • DAPPER2 antibody
    • DPR2 antibody
    • FLJ31232 antibody
    • MGC133141 antibody
    • MGC133142 antibody
    • RP11 503C24.7 antibody
    see all

Images

  • Anti-Dact2 antibody (ab79042) at 1 µg/ml + SK N SH cell lysate at 15 µg

    Predicted band size : 83 kDa
    Observed band size : 83 kDa
  • Immunofluorescence of Dact2 in Human Brain cells using ab79042 at 20 ug/ml.

References

This product has been referenced in:
  • Guo YL  et al. Aberrant methylation of DACT1 and DACT2 are associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma. J Biomed Sci 24:6 (2017). IHC-P ; Human . Read more (PubMed: 28077137) »
  • Hou J  et al. DACT2 is a candidate tumor suppressor and prognostic marker in esophageal squamous cell carcinoma. Cancer Prev Res (Phila) 6:791-800 (2013). Read more (PubMed: 23803417) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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