• Product nameAnti-DAP12 antibody
    See all DAP12 primary antibodies
  • Description
    Rabbit polyclonal to DAP12
  • Specificityab25098 recognises recombinant and natural DAP12.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Rat
  • Immunogen

    E. coli expressed recombinant fragment:


    , corresponding to amino acids 28/40 of Rat DAP12

  • Positive control
    • Day 8 tubular interstitial nephritis model


  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 0.1% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab25098 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 13 kDa.


  • FunctionNon-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation.
  • Tissue specificityExpressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum.
  • Involvement in diseaseDefects in TYROBP are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) [MIM:221770]; also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns.
  • Sequence similaritiesBelongs to the TYROBP family.
  • Post-translational
    Tyrosine phosphorylated.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • DAP 12 antibody
    • DAP12 antibody
    • DNAX activation protein 12 antibody
    • DNAX-activation protein 12 antibody
    • KAR-associated protein antibody
    • KARAP antibody
    • Killer activating receptor associated protein antibody
    • Killer-activating receptor-associated protein antibody
    • PLOSL antibody
    • TYOBP_HUMAN antibody
    • TYRO protein tyrosine kinase binding protein antibody
    • TYRO protein tyrosine kinase-binding protein antibody
    • TYROBP antibody
    see all

Anti-DAP12 antibody images

  • All lanes : Anti-DAP12 antibody (ab25098) at 1/1000 dilution

    Lane 1 : Day 3 tubular interstitial nephritis model
    Lane 2 : Day 8 tubular interstitial nephritis model
    Lane 3 : Day 10 tubular interstitial nephritis model

    Predicted band size : 13 kDa
    Observed band size : 13 kDa

References for Anti-DAP12 antibody (ab25098)

ab25098 has not yet been referenced specifically in any publications.

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