FunctionRNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.
Tissue specificityTestis specific.
Involvement in diseaseDefects in DAZ2 may be a cause of spermatogenic failure Y-linked type 2 (SPGFY2) [MIM:415000]. It is a disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. Note=AZFc deletions in the Yq11.23 region including the DAZ genes are the most common known genetic cause of human male infertility.
Sequence similaritiesBelongs to the RRM DAZ family. Contains 15 DAZ-like domains. Contains 1 RRM (RNA recognition motif) domain.
DomainThe DAZ-like repeats are essential and mediate the interaction with DAZAP1 and DAZAP2.
Cellular localizationCytoplasm. Nucleus. Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.