Overview

  • Product name
    Anti-DAZ2 antibody - C-terminal
    See all DAZ2 primary antibodies
  • Description
    Rabbit polyclonal to DAZ2 - C-terminal
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human DAZ2 aa 325-354 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q13117

  • Positive control
    • 293 cell lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab170660 was purified through a protein A column, followed by peptide affinity purification
  • Clonality
    Polyclonal
  • Isotype
    IgG

Applications

Our Abpromise guarantee covers the use of ab170660 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 63 kDa.

Target

  • Function
    RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.
  • Tissue specificity
    Testis specific.
  • Involvement in disease
    Defects in DAZ2 may be a cause of spermatogenic failure Y-linked type 2 (SPGFY2) [MIM:415000]. It is a disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. Note=AZFc deletions in the Yq11.23 region including the DAZ genes are the most common known genetic cause of human male infertility.
  • Sequence similarities
    Belongs to the RRM DAZ family.
    Contains 15 DAZ-like domains.
    Contains 1 RRM (RNA recognition motif) domain.
  • Domain
    The DAZ-like repeats are essential and mediate the interaction with DAZAP1 and DAZAP2.
  • Cellular localization
    Cytoplasm. Nucleus. Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.
  • Information by UniProt
  • Database links
  • Alternative names
    • DAZ2 antibody
    • DAZ2_HUMAN antibody
    • DAZ3 antibody
    • Deleted in azoospermia 2 antibody
    • Deleted in azoospermia protein 2 antibody
    • Deleted in azoospermia protein 3 antibody
    • MGC126442 antibody
    • pDP1678 antibody
    see all

Images

  • Anti-DAZ2 antibody - C-terminal (ab170660) at 1/100 dilution + 293 cell lysate at 35 µg

    Predicted band size : 63 kDa

References

ab170660 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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