1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
1/100 - 1/1000.
RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.
Involvement in disease
Spermatogenic failure Y-linked 2
Belongs to the RRM DAZ family. Contains 12 DAZ-like domains. Contains 1 RRM (RNA recognition motif) domain.
The DAZ-like repeats are essential and mediate the interaction with DAZAP1 and DAZAP2.
Cytoplasm. Nucleus. Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.