Overview

  • Product name
    Anti-DAZ3 antibody - C-terminal
    See all DAZ3 primary antibodies
  • Description
    Rabbit polyclonal to DAZ3 - C-terminal
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human DAZ3 aa 396-426 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q9NR90

  • Positive control
    • CEM cell lysate, formalin fixed and paraffin embedded Human testis tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab170678 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 55 kDa.
IHC-P 1/10 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.
  • Tissue specificity
    Testis specific.
  • Involvement in disease
    Spermatogenic failure Y-linked 2
  • Sequence similarities
    Belongs to the RRM DAZ family.
    Contains 12 DAZ-like domains.
    Contains 1 RRM (RNA recognition motif) domain.
  • Domain
    The DAZ-like repeats are essential and mediate the interaction with DAZAP1 and DAZAP2.
  • Cellular localization
    Cytoplasm. Nucleus. Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.
  • Information by UniProt
  • Database links
  • Alternative names
    • DAZ3 antibody
    • DAZ3_HUMAN antibody
    • deleted in azoospermia 3 antibody
    • Deleted in azoospermia protein 3 antibody
    • MGC126441 antibody
    • pDP1679 antibody
    see all

Images

  • Immunohistochemistry analysis of formalin fixed and paraffin embedded Human testis tissue with ab170678 at 1/10 diluion followed by peroxidase conjugation of the secondary antibody and DAB staining

  • Anti-DAZ3 antibody - C-terminal (ab170678) at 1/100 dilution + CEM cell lysate at 35 µg

    Predicted band size : 55 kDa

References

ab170678 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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