Overview

  • Product nameAnti-DCK antibody [2243C2]
    See all DCK primary antibodies
  • Description
    Mouse monoclonal [2243C2] to DCK
  • Tested applicationsSuitable for: WB, Dot blotmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment (N-terminal).

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at 4°C (stable for up to 12 months). Store at -20°C or -80°C.
  • Storage bufferPreservative: 0.05% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • PurityProtein G purified
  • Purification notesPurified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG depleted |(approximately 95%) feta bovine serum. Filtered through a 0.22 micrometer membrane.
  • ClonalityMonoclonal
  • Clone number2243C2
  • IsotypeIgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab51517 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Predicted molecular weight: 31 kDa.
Dot blot Use at an assay dependent dilution.

Target

  • FunctionRequired for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
  • Sequence similaritiesBelongs to the DCK/DGK family.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • dCK antibody
    • DCK protein antibody
    • DCK_HUMAN antibody
    • Deoxycytidine kinase antibody
    • Deoxynucleoside kinase antibody
    • EC 2.7.1 antibody
    • EC 2.7.1.74 antibody
    • MGC117410 antibody
    • MGC138632 antibody
    • OTTHUMP00000219118 antibody
    • OTTHUMP00000219119 antibody
    see all

Anti-DCK antibody [2243C2] images

  • Anti-DCK antibody [2243C2] (ab51517) + Immunized recombinant protein

    Predicted band size : 31 kDa
    Observed band size : 31 kDa

References for Anti-DCK antibody [2243C2] (ab51517)

This product has been referenced in:
  • Neschadim A  et al. Cell fate control gene therapy based on engineered variants of human deoxycytidine kinase. Mol Ther 20:1002-13 (2012). WB ; Human . Read more (PubMed: 22273576) »
  • Likar Y  et al. A new pyrimidine-specific reporter gene: a mutated human deoxycytidine kinase suitable for PET during treatment with acycloguanosine-based cytotoxic drugs. J Nucl Med 51:1395-403 (2010). WB ; Human . Read more (PubMed: 20810757) »

See all 2 Publications for this product

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"