Overview

  • Product name
    Anti-Dcp2 antibody - C-terminal
    See all Dcp2 primary antibodies
  • Description
    Rabbit polyclonal to Dcp2 - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Dcp2 (C terminal). The exact sequence is proprietary. The peptide corresponds to 18 amino acids.
    Database link: Q8IU60

  • Positive control
    • Small intestine and testis tissue. 293 cell lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab189966 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 48 kDa.
IHC-P Use a concentration of 5 - 20 µg/ml.

Target

  • Function
    Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking a RNA moiety.
  • Sequence similarities
    Belongs to the Nudix hydrolase family. DCP2 subfamily.
    Contains 1 nudix hydrolase domain.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Cytoplasm > P-body. Nucleus. Predominantly cytoplasmic, in processing bodies (PB). A minor amount is nuclear.
  • Information by UniProt
  • Database links
  • Alternative names
    • DCP2 antibody
    • DCP2 decapping enzyme homolog (S. cerevisiae) antibody
    • DCP2, S. cerevisiae, homolog of antibody
    • DCP2_HUMAN antibody
    • decapping enzyme 2, S. cerevisiae, homolog of antibody
    • decapping enzyme homolog (S. cerevisiae) antibody
    • FLJ33245 antibody
    • hDpc antibody
    • m7GpppN-mRNA hydrolase antibody
    • mRNA decapping enzyme 2 antibody
    • mRNA-decapping enzyme 2 antibody
    • Nucleoside diphosphate-linked moiety X motif 20 antibody
    • nudix (nucleoside diphosphate linked moiety X)-type motif 20 antibody
    • Nudix motif 20 antibody
    • NUDT20 antibody
    see all

Images

  • Immunohistochemistry of formalin-fixed, paraffin-embedded Human small intestine tissue labeling Dcp2 with ab189966 at 10 µg/ml.

  • Immunohistochemistry of Human testis tissue labeling Dcp2 with ab189966 at 20 µg/ml. Detection by immunofluorescence.

  • All lanes : Anti-Dcp2 antibody - C-terminal (ab189966) at 1 µg/ml

    Lane 1 : 293 cell lysate
    Lane 2 : 293 cell lysate with Blocking peptide

    Predicted band size: 48 kDa

References

ab189966 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab189966.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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