Overview

  • Product nameAnti-DcR1 antibody
    See all DcR1 primary antibodies
  • Description
    Goat polyclonal to DcR1
  • Specificity<0.2% cross-reactivity to TRAIL R2 peptide of the same region. Not likely to bind TRAIL R1 due to low sequence homology in this region. May bind TRAIL R4. May cross react to mouse TRAIL R3 as antibody binds to a similar size protein from mouse spleen on Westerns.
  • Tested applicationsSuitable for: ELISA, Flow Cyt, ICC, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    EVPQQTVAPQQQRHSFKGEECPAGSHRSEHTC

    , corresponding to N terminal amino acids 33-64 of Human DcR1.

  • Positive control
    • Human embryonic kidney cell line-293 or human T-cell line Jurkatt.
  • General notesTRAIL R3 = "TNF Related Apoptosis Inducing Ligand Receptor 3"

Properties

Applications

Our Abpromise guarantee covers the use of ab1674 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
Flow Cyt
ICC
WB
  • Application notesELISA: Use at a dilution > 1/150000.
    Flow Cyt: Use at an assay dependant dilution.
    ICC: 1/300.
    WB: 1/1000.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceDcR1 / TRAIL-R3 / TRID / LIT is one of the two putative decoy receptors identified for TRAIL, one of the members of TNF family of apoptosis inducing proteins. The other putative decoy receptor is called DcR2 / TRUNDD / TRAIL-R4. DcR1 is attached to the cell surface through glycophospholipid anchor. It has the extracellular TRAIL binding domain but lacks the cytoplasmic domain to induce apoptotic signal. Hence overexpression of DcR1 inhibits the TRAIL induced apoptosis.
    • Cellular localizationCell Membrane and Cytoplasmic
    • Database links
    • Alternative names
      • Antagonist decoy receptor for TRAIL/Apo 2L antibody
      • CD263 antibody
      • Cytotoxic TRAIL receptor 3 antibody
      • DCR1 antibody
      • DCR1 TNFR antibody
      • Decoy Receptor 1 antibody
      • Decoy TRAIL receptor without death domain antibody
      • LIT antibody
      • Lymphocyte inhibitor of TRAIL antibody
      • MGC149501 antibody
      • MGC149502 antibody
      • TNF related apoptosis inducing ligand receptor 3 antibody
      • TNF-re ated apoptosis inducing ligand receptor 3 antibody
      • TNFRSF10C antibody
      • TRAIL R3 antibody
      • TRAIL receptor 3 antibody
      • TRAILR3 antibody
      • TRID antibody
      • Tumor necrosis factor receptor superfamily member 10C antibody
      • Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain antibody
      see all

    Anti-DcR1 antibody images

    • ab1674 recognizes a 66kDa band of expected size in Lane 1 containing TRAIL-3R-Fc protein and showed minimal or no crossreactivity to TRAIL-2R-Fc protein in Lane 2.

    References for Anti-DcR1 antibody (ab1674)

    ab1674 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"