The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and DcR1, catalog ab5808. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Antagonist decoy receptor for TRAIL/Apo 2L
Cytotoxic TRAIL receptor 3
Decoy Receptor 1
Decoy TRAIL receptor without death domain
Lymphocyte inhibitor of TRAIL
TNF related apoptosis inducing ligand receptor 3
TNF-re ated apoptosis inducing ligand receptor 3
TRAIL receptor 3
Tumor necrosis factor receptor superfamily member 10C
Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
DcR1 / TRAIL-R3 / TRID / LIT is one of the two putative decoy receptors identified for TRAIL, one of the members of TNF family of apoptosis inducing proteins. The other putative decoy receptor is called DcR2 / TRUNDD / TRAIL-R4. DcR1 is attached to the cell surface through glycophospholipid anchor. It has the extracellular TRAIL binding domain but lacks the cytoplasmic domain to induce apoptotic signal. Hence overexpression of DcR1 inhibits the TRAIL induced apoptosis.
Cell Membrane and Cytoplasmic
References for DcR1 peptide (ab5849)
has not yet been referenced specifically in any publications.
Publishing research using ab5849? Please let us know so that we can cite the reference in this datasheet.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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