Anti-DcR2 antibody [EPR3588(2)] (ab108421)


  • Product name
    Anti-DcR2 antibody [EPR3588(2)]
    See all DcR2 primary antibodies
  • Description
    Rabbit monoclonal [EPR3588(2)] to DcR2
  • Tested applications
    Suitable for: WB, IHC-P, ICCmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) (internal sequence)

  • Positive control
    • Fetal liver, Fetal kidney and Human prostate lysates; Human kidney and tonsil tissue
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.



Our Abpromise guarantee covers the use of ab108421 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 42 kDa.
IHC-P 1/250 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC 1/50 - 1/100.


  • Function
    Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.
  • Tissue specificity
    Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.
  • Sequence similarities
    Contains 1 death domain.
    Contains 3 TNFR-Cys repeats.
  • Cellular localization
  • Information by UniProt
  • Database links
  • Alternative names
    • CD 264 antibody
    • CD264 antibody
    • DcR 2 antibody
    • DcR2 antibody
    • Decoy receptor 2 antibody
    • Decoy with truncated death domain antibody
    • OTTHUMP00000123528 antibody
    • TNF receptor related receptor for TRAIL antibody
    • TNF related apoptosis inducing ligand receptor 4 antibody
    • TNF-related apoptosis-inducing ligand receptor 4 antibody
    • TNFRSF 10D antibody
    • TNFRSF10D antibody
    • TR10D_HUMAN antibody
    • TRAIL R4 antibody
    • TRAIL receptor 4 antibody
    • TRAIL receptor with a truncated death domain antibody
    • TRAIL-R4 antibody
    • TRAILR4 antibody
    • TRUNDD antibody
    • Tumor necrosis factor receptor superfamily member 10D antibody
    • Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain antibody
    see all

Anti-DcR2 antibody [EPR3588(2)] images

  • All lanes : Anti-DcR2 antibody [EPR3588(2)] (ab108421) at 1/1000 dilution

    Lane 1 : Fetal liver lysate
    Lane 2 : Fetal kidney lysate
    Lane 3 : Human prostate lysate

    Lysates/proteins at 10 µg per lane.

    HRP labelled goat anti-rabbit at 1/2000 dilution

    Predicted band size : 42 kDa
  • ab108421, at 1/250 dilution, staining DcR2 in paraffin-embedded Human kidney tissue by Immunohistochemistry.
  • ab108421, at 1/250 dilution, staining DcR2 in paraffin-embedded Human tonsil tissue by Immunohistochemistry.

References for Anti-DcR2 antibody [EPR3588(2)] (ab108421)

ab108421 has not yet been referenced specifically in any publications.

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