The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
PBS with 0.1% BSA 0.02% sodium azide pH7.2
Decoy receptor 2
Decoy with truncated death domain
TNF receptor related receptor for TRAIL
TNF related apoptosis inducing ligand receptor 4
TNF-related apoptosis-inducing ligand receptor 4
TRAIL receptor 4
TRAIL receptor with a truncated death domain
Tumor necrosis factor receptor superfamily member 10D
Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
FunctionReceptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.
Tissue specificityWidely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.
Sequence similaritiesContains 1 death domain. Contains 3 TNFR-Cys repeats.