Overview

  • Product name
  • Description
    Mouse monoclonal to DcR3
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 32-142 of Human DcR3

  • General notes

    Abcam is committed to meeting high standards of ethical manufacturing and has decided to discontinue this product by June 2019 as it has been generated by the ascites method. We are sorry for any inconvenience this may cause. We would recommend antibody ab8405 as a replacement.

Properties

Applications

Our Abpromise guarantee covers the use of ab57956 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IHC-P
  • Application notes
    WB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Decoy receptor for the cytotoxic ligands TNFS14/LIGHT and TNFSF6/FASL. Protects against apoptosis.
    • Tissue specificity
      Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.
    • Sequence similarities
      Contains 4 TNFR-Cys repeats.
    • Cellular localization
      Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • DcR3 antibody
      • Decoy receptor 3 antibody
      • Decoy receptor for Fas ligand antibody
      • DJ583P15.1.1 antibody
      • M68 antibody
      • M68E antibody
      • OTTHUMP00000031583 antibody
      • TNF6B_HUMAN antibody
      • TNFRSF6B antibody
      • TR6 antibody
      • Tumor necrosis factor receptor superfamily member 6B antibody
      • Tumor necrosis factor receptor superfamily member 6b decoy antibody
      • UNQ186/PRO212 antibody
      see all

    Images

    • DcR3 antibody (ab57956) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human tonsil.
    • Western blot against tagged recombinant protein immunogen using ab57956 DcR3 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

    References

    This product has been referenced in:
    • Zhang X  et al. Protocadherin ? A3 is expressed in follicular lymphoma irrespective of BCL2 status and is associated with tumor cell growth. Mol Med Rep 14:4622-4628 (2016). IHC-P ; Human . Read more (PubMed: 27748813) »
    • Chang WC  et al. Expression of decoy receptor 3 in diffuse sclerosing variant of papillary thyroid carcinoma: correlation with M2 macrophage differentiation and lymphatic invasion. Thyroid 23:720-6 (2013). Read more (PubMed: 23186064) »

    See all 2 Publications for this product

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab57956.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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