• Product nameAnti-DCTN1 antibody
    See all DCTN1 primary antibodies
  • Description
    Mouse monoclonal to DCTN1
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Human
  • Immunogen

    Recombinant full length (aa 1-199) human DCTN1 with tag (AAH06163).

  • Positive control
    • Recombinant DCTN1.



Our Abpromise guarantee covers the use of ab54738 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesELISA: Use at an assay dependent dilution.
    WB: 1/500 - 1/1000. Detects a band of approximately 48 kDa (predicted molecular weight: 142 kDa).
    This antibody has only been tested in WB against the recombinant protein used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionRequired for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
    • Tissue specificityBrain.
    • Involvement in diseaseDefects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B) [MIM:607641]; also known as progressive lower motor neuron disease (PLMND). HMN7B is a neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.
      Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS) [MIM:105400]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.
      Defects in DCTN1 are the cause of Perry syndrome (PERRYS) [MIM:168605]; also called parkinsonism with alveolar hypoventilation and mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally.
    • Sequence similaritiesBelongs to the dynactin 150 kDa subunit family.
      Contains 1 CAP-Gly domain.
    • Post-translational
      Ubiquitinated by a SCF complex containing FBXL5, leading to its degradation by the proteasome.
    • Cellular localizationCytoplasm. Cytoplasm > cytoskeleton.
    • Information by UniProt
    • Database links
    • Alternative names
      • 150 kDa dynein associated polypeptide antibody
      • 150 kDa dynein-associated polypeptide antibody
      • DAP 150 antibody
      • DAP-150 antibody
      • DAP150 antibody
      • DCTN 1 antibody
      • DCTN1 antibody
      • DCTN1_HUMAN antibody
      • DP 150 antibody
      • DP-150 antibody
      • DP150 antibody
      • Dynactin 1 (p150 Glued (Drosophila) homolog) antibody
      • Dynactin 1 (p150 glued homolog Drosophila) antibody
      • Dynactin 1 antibody
      • Dynactin subunit 1 antibody
      • Dynactin1 antibody
      • HMN7B antibody
      • p135 antibody
      • p150 Glued (Drosophila) homolog antibody
      • p150 glued antibody
      • p150 glued homolog antibody
      • p150(GLUED) DROSOPHILA HOMOLOG OF antibody
      • p150-glued antibody
      • p150glued antibody
      see all

    Anti-DCTN1 antibody images

    • Anti-DCTN1 antibody (ab54738) at 1/500 dilution + recombinant DCTN1 at 0.2 µg

      Goat Anti-Mouse IgG (H&L)-HRP at 1/5000 dilution

      Predicted band size : 142 kDa
      Observed band size : 48 kDa (why is the actual band size different from the predicted?)

    References for Anti-DCTN1 antibody (ab54738)

    ab54738 has not yet been referenced specifically in any publications.

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