• Product name
  • Description
    Goat polyclonal to DCXR
  • Tested applications
    Suitable for: IHC-P, ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Guinea pig, Hamster
  • Immunogen

    Synthetic peptide:


    , corresponding to amino acids 232-244 of Human DCXR.

  • Positive control
    • Hela and Human Kidney lysates.



Our Abpromise guarantee covers the use of ab11800 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    ELISA: 1/32000.
    WB: Use at a concentration of 0.1 - 0.5 µg/ml. Detects a band of approximately 28 kDa in Hela and Human Kidney lysates.
    IHC-P: Use at a concentration of 1 - 2 µg/ml. In paraffin embedded Human Kidney, stains membrane / cytoplasm in epithelial cells of renal glomeruli and tubules.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
    • Tissue specificity
      Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis.
    • Involvement in disease
      Note=The enzyme defect in pentosuria has been shown to involve L-xylulose reductase. Essential pentosuria is an inborn error of metabolism characterized by the excessive urinary excretion of the pentose L-xylulose.
    • Sequence similarities
      Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    • Cellular localization
      Membrane. Probably recruited to membranes via an interaction with phosphatidylinositol.
    • Information by UniProt
    • Database links
    • Alternative names
      • Carbonyl reductase 2 antibody
      • Carbonyl reductase II antibody
      • DCR antibody
      • Dcxr antibody
      • DCXR_HUMAN antibody
      • Dicarbonyl and L xylulose reductase antibody
      • Dicarbonyl L xylulose reductase antibody
      • Dicarbonyl/ L xylulose reductase antibody
      • Dicarbonyl/L-xylulose reductase antibody
      • HCR2 antibody
      • HCRII antibody
      • Human carbonyl reductase 2 antibody
      • kiDCR antibody
      • Kidney dicarbonyl reductase antibody
      • L xylulose reductase antibody
      • L-xylulose reductase antibody
      • P34H antibody
      • PNTSU antibody
      • SDR20C1 antibody
      • Short chain dehydrogenase/reductase family 20C member 1 antibody
      • Sperm surface protein P34H antibody
      • XR antibody
      see all

    Anti-DCXR antibody images

    • Ab11800 staining (0.1µg/ml) of Human Kidney lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
    • Ab11800 (1ug/ml) staining human DCXR in human kidney by immunohistochemistry using paraffin embedded tissue.

      Microwaved antigen retrieval with citrate buffer, pH6, HRP-staining.

    References for Anti-DCXR antibody (ab11800)

    ab11800 has not yet been referenced specifically in any publications.

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