Overview

  • Product nameAnti-DDR2 antibody
    See all DDR2 primary antibodies
  • Description
    Rabbit polyclonal to DDR2
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide CYFRSEASEWEPNAISF conjugated to KLH, corresponding to amino acids 304-320 of Human DDR2.

  • Positive control
    • HL60 cell lysate.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • PurityProtein G purified
  • Purification notesThis antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab5520 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 97 kDa (predicted molecular weight: 102 kDa).

Target

  • FunctionThis tyrosine kinase receptor for fibrillar collagen mediates fibroblast migration and proliferation. Contributes to cutaneous wound healing.
  • Tissue specificityThe major 10 kDa transcript is expressed in high levels in heart and lung, less in brain, placenta, liver, skeletal muscle, pancreas, and kidney.
  • Involvement in diseaseDefects in DDR2 are the cause of spondyloepimetaphyseal dysplasia short limb-hand type (SEMD-SL) [MIM:271665]. A bone disease characterized by short-limbed dwarfism, a narrow chest with pectus excavatum, brachydactyly in the hands and feet, a characteristic craniofacial appearance and premature calcifications. The radiological findings are distinctive and comprise short long bones throughout the skeleton with striking epiphyses that are stippled, flattened and fragmented and flared, irregular metaphyses. Platyspondyly in the spine with wide intervertebral spaces is observed and some vertebral bodies are pear-shaped with central humps, anterior protrusions and posterior scalloping.
  • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    Contains 1 F5/8 type C domain.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD167 antigen-like family member B antibody
    • CD167b antibody
    • CD167b antigen antibody
    • Cell migration inducing protein 20 antibody
    • DDR 2 antibody
    • DDR2 antibody
    • DDR2_HUMAN antibody
    • Discoidin domain containing receptor 2 antibody
    • Discoidin domain receptor 2 antibody
    • Discoidin domain receptor family member 2 antibody
    • discoidin domain receptor tyrosine kinase 2 antibody
    • Discoidin domain-containing receptor 2 antibody
    • discoidin domain-containing receptor tyrosine kinase 2 antibody
    • Hydroxyaryl protein kinase antibody
    • MIG20a antibody
    • Migration inducing gene 16 protein antibody
    • Neurotrophic tyrosine kinase antibody
    • Neurotrophic tyrosine kinase receptor related 3 antibody
    • NTRKR 3 antibody
    • NTRKR3 antibody
    • Receptor protein tyrosine kinase TKT antibody
    • Receptor protein-tyrosine kinase TKT antibody
    • Receptor related 3 antibody
    • receptor-related 3 antibody
    • TKT antibody
    • TYRO 10 antibody
    • TYRO10 antibody
    • Tyrosine kinase receptor related to neurotrophic TRK antibody
    • Tyrosine protein kinase TYRO 10 antibody
    • Tyrosine protein kinase TYRO10 antibody
    • Tyrosine-protein kinase TYRO10 antibody
    • Tyrosylprotein kinase antibody
    see all

Anti-DDR2 antibody images



  • Predicted band size : 102 kDa


    ab5520 at a 1/100 dilution staining approximately 97kDa band of TYRO 10 in HL60 cell lysate by Western blot (ECL).

References for Anti-DDR2 antibody (ab5520)

This product has been referenced in:
  • Jubeck B  et al. Type II collagen levels correlate with mineralization by articular cartilage vesicles. Arthritis Rheum 60:2741-6 (2009). WB ; Human, Pig . Read more (PubMed: 19714645) »
  • Husse B  et al. Cyclical mechanical stretch modulates expression of collagen I and collagen III by PKC and tyrosine kinase in cardiac fibroblasts. Am J Physiol Regul Integr Comp Physiol 293:R1898-907 (2007). Read more (PubMed: 17686880) »

See all 3 Publications for this product

Product Wall

Thank you for your e-mail, we had difficulty opening this attachement and I needed the help for our IT department, can you please not send your claim sheets as attached files but copy them and paste them in an e-mail? Can you please provide me with:...

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Thank you for your enquiry I am sorry to hear that you have been experiencing problems with this product. From the information provided it is difficult to offer specific advice, as the information is too sparse. However from the data that you have prov...

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Thank you for your patience. I forwarded the details of your protocol and your results found to the originator of ab5520. They predict that the 95 kDa band is DDR2. The appearance of a single additional band with a difference of +10 kDa could suggest a...

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The peptide sequence is CYFRSEASEWEPNAISF of human DDR2 aa304-320 (Q16832). Our datasheet has been corrected. Thank you again for spotting this error. Please also see my comments for ab5520.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"