Overview

  • Product name
  • Description
    Rabbit polyclonal to DDX26
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rabbit, Horse, Cow, Pig, Chimpanzee, Rhesus monkey, Gorilla, Opossum, Orangutan, Elephant
  • Immunogen

    Synthetic peptide corresponding to a region between residue 750 and 800 of Human DDX26 (NP_036273.1).

  • Positive control
    • Linitis Plastica Stomach Cancer, Ovarian Carcinoma, Pancreatic Islet Cell Tumor, Prostate Carcinoma.
  • General notes
    The concentration of IgG is less than or equal to 1 mg/ml.

Properties

Applications

Our Abpromise guarantee covers the use of ab114075 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Antigen retrieval is recommended. Likely to work with frozen sections In some cases, the antibody may be diluted further than indicated.

Target

  • Function
    Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth.
  • Tissue specificity
    Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • Sequence similarities
    Belongs to the Integrator subunit 6 family.
    Contains 1 VWFA domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • DBI 1 antibody
    • DBI-1 antibody
    • DBI1 antibody
    • DDX26 antibody
    • DDX26A antibody
    • DEAD box protein antibody
    • DEAD/H (Asp Glu Ala Asp/His) box polypeptide 26 antibody
    • Deleted in cancer 1 antibody
    • DICE1 antibody
    • DKFZp434B105 antibody
    • HDB antibody
    • Int6 antibody
    • INT6_HUMAN antibody
    • Integrator complex subunit 6 antibody
    • INTS 6 antibody
    • ints6 antibody
    • Notchl2 antibody
    • OTTHUMP00000018439 antibody
    • OTTHUMP00000215034 antibody
    • OTTHUMP00000215036 antibody
    • Protein DDX26 antibody
    • Protein deleted in cancer 1 antibody
    • RNA helicase HDB antibody
    see all

Images

  • ab114075 at 1/250 dilution staining DDX26 in Formalin-Fixed, Paraffin-Embedded prostate carcinoma tissue by Immunohistochemistry. Detection utilised DAB.

References

ab114075 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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