Overview

  • Product name
  • Description
    Rabbit polyclonal to DEDD
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 129-193 of Human DEDD

  • Positive control
    • 293T, HeLa, HepG2, MOLT4 and Raji whole cell lysates

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab96362 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 37 kDa.

Target

  • Function
    A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro.
  • Tissue specificity
    Widely expressed with highest levels in testis.
  • Sequence similarities
    Contains 1 DED (death effector) domain.
  • Post-translational
    modifications
    Exists predominantly in a mono- or diubiquitinated form.
  • Cellular localization
    Cytoplasm. Nucleus > nucleolus. Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • CASP8IP1 antibody
    • Death effector domain containing antibody
    • Death effector domain containing protein antibody
    • Death effector domain containing testicular molecule antibody
    • Death effector domain-containing protein antibody
    • Death effector domain-containing testicular molecule antibody
    • DEDD 1 antibody
    • dedD antibody
    • DEDD_HUMAN antibody
    • DEDD1 antibody
    • DEDPro 1 antibody
    • DEDPro1 antibody
    • DEFT antibody
    • FLDED 1 antibody
    • FLDED-1 antibody
    • FLDED1 antibody
    • KE 05 antibody
    • KE05 antibody
    • OTTHUMP00000031822 antibody
    see all

Images

  • Anti-DEDD antibody (ab96362) at 1/1000 dilution + Raji whole cell lysate at 30 µg

    Predicted band size : 37 kDa

References

ab96362 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab96362.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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