Overview

  • Product nameAnti-DEDD2 antibody
    See all DEDD2 primary antibodies
  • Description
    Rabbit polyclonal to DEDD2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 179-228 (PQQQSEPARP SSEGKVTCDI RLRVRAEYCE HGPALEQGVA SRRPQALARQ) of Human DEDD2 (NP_579874)

  • Positive control
    • Human fetal lung lysate

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab104350 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 36 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • RelevanceApoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.
  • Cellular localizationNuclear, accumulated in subnuclear structures resembling nucleoli.
  • Database links
  • Alternative names
    • Death effector domain containing 2 antibody
    • Death effector domain-containing DNA-binding protein antibody
    • Death effector domain-containing protein antibody
    • Death effector domain-containing testicular protein antibody
    • DED containing protein FLAME 3 antibody
    • DEFT antibody
    • DNA binding death effector domain containing protein 2 antibody
    • DNA-binding death effector domain-containing protein 2 antibody
    • FADD like anti apoptotic molecule 3 antibody
    • FLAME 3 antibody
    see all

Anti-DEDD2 antibody images

  • Anti-DEDD2 antibody (ab104350) at 1 µg/ml + Human fetal lung lysate at 10 µg

    Predicted band size : 36 kDa

References for Anti-DEDD2 antibody (ab104350)

ab104350 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"