• Product name
    Anti-DEDD2 antibody
  • Description
    Rabbit polyclonal to DEDD2
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A peptide corresponding to 11 amino acids near the amino-terminus of human DEDD2.

  • Positive control
    • RAW264.7 cell lysate.


  • Form
  • Storage instructions
    Shipped at 4°C. Store at +4°C.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
  • Isotype
  • Research areas


Our Abpromise guarantee covers the use of ab36858 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 26 kDa (predicted molecular weight: 36 kDa).


  • Relevance
    Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.
  • Cellular localization
    Nuclear, accumulated in subnuclear structures resembling nucleoli.
  • Database links
  • Alternative names
    • Death effector domain containing 2 antibody
    • Death effector domain-containing DNA-binding protein antibody
    • Death effector domain-containing protein antibody
    • Death effector domain-containing testicular protein antibody
    • DED containing protein FLAME 3 antibody
    • DEFT antibody
    • DNA binding death effector domain containing protein 2 antibody
    • DNA-binding death effector domain-containing protein 2 antibody
    • FADD like anti apoptotic molecule 3 antibody
    • FLAME 3 antibody
    see all


  • Lane 1 : Anti-DEDD2 antibody (ab36858) at 0.5 µg/ml
    Lane 2 : Anti-DEDD2 antibody (ab36858) at 1 µg/ml
    Lane 3 : Anti-DEDD2 antibody (ab36858) at 2 µg/ml

    Lane 1 : RAW264.7 cell lysate
    Lane 2 : RAW264.7 cell lysate
    Lane 3 : RAW264.7 cell lysate

    Lysates/proteins at 15 µg/ml per lane.

    Anti-rabbit IgG HRP at 1/10000 dilution

    Predicted band size : 36 kDa
    Observed band size : 26 kDa (why is the actual band size different from the predicted?)


ab36858 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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