Overview

  • Product nameAnti-DEK antibody
    See all DEK primary antibodies
  • Description
    Rabbit polyclonal to DEK
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Rhesus monkey, Gorilla
  • Immunogen

    Synthetic peptide corresponding to a region between residue 225 and 275 of Human DEK (NP_003463.1).

  • Positive control
    • Human Anaplastic Thyroid Carcinoma, Bladder Cell Carcinoma, Breast Carcinoma, Ovarian Carcinoma, Prostate Carcinoma, Skin Squamous Cell Carcinoma and Stomach Adenocarcinoma.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab85407 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionInvolved in chromatin organization.
    • Tissue specificityUbiquitous. Expressed at relatively high levels.
    • Involvement in diseaseA chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK-NUP214 fusion gene (PubMed:1549122).
    • Sequence similaritiesContains 1 SAP domain.
    • Post-translational
      modifications
      Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase, and weakens the binding of DEK to DNA.
    • Cellular localizationNucleus. Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.
    • Information by UniProt
    • Database links
    • Alternative names
      • D6S231E antibody
      • Dek antibody
      • DEK gene antibody
      • DEK oncogene antibody
      • DEK oncogene DNA binding antibody
      • DEK_HUMAN antibody
      • Protein DEK antibody
      see all

    Anti-DEK antibody images

    • ab85407, at 1/250 dilution, staining DEK in formalin-fixed, paraffin-embedded human stomach carcinoma by Immunohistochemistry using DAB staining.
    • ab85407, at 1/250 dilution, staining DEK in formalin-fixed, paraffin-embedded human prostate carcinoma by Immunohistochemistry using DAB staining.

    References for Anti-DEK antibody (ab85407)

    ab85407 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab85407.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"