Overview

  • Product nameAnti-delta 1 Catenin antibody
    See all delta 1 Catenin primary antibodies
  • Description
    Rabbit polyclonal to delta 1 Catenin
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthesized non phosphopeptide derived from human delta 1 Catenin around the phosphorylation site of tyrosine 228 (D-N-YP-G-S).

  • Positive control
    • Extracts from HuvEc cells, human brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab74124 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 108 kDa (predicted molecular weight: 108 kDa).
ELISA 1/5000.
IHC-P 1/50 - 1/100.

Target

  • FunctionBinds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
  • Tissue specificityExpressed in vascular endothelium.
  • Sequence similaritiesBelongs to the beta-catenin family.
    Contains 10 ARM repeats.
  • DomainA possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.
  • Post-translational
    modifications
    Phosphorylated by protein-tyrosine kinases. Dephosphorylated by PTPRJ.
  • Cellular localizationCytoplasm. Nucleus. Cell membrane. Interaction with GLIS2 promotes nuclear translocation (By similarity). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cadherin associated Src substrate antibody
    • Cadherin-associated Src substrate antibody
    • CAS antibody
    • Catenin (cadherin associated protein) delta 1 antibody
    • Catenin delta 1 antibody
    • Catenin delta antibody
    • Catenin delta-1 antibody
    • CTND1_HUMAN antibody
    • CTNND 1 antibody
    • CTNND antibody
    • CTNND1 antibody
    • KIAA0384 antibody
    • p120 antibody
    • P120 CAS antibody
    • p120 catenin antibody
    • P120 CTN antibody
    • p120(cas) antibody
    • p120(ctn) antibody
    • P120CAS antibody
    • P120CTN antibody
    see all

Anti-delta 1 Catenin antibody images

  • All lanes : Anti-delta 1 Catenin antibody (ab74124) at 1/500 dilution

    Lane 1 : Extracts from HuvEc cells
    Lane 2 : Extracts from HuvEc cells, plus immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 108 kDa
    Observed band size : 108 kDa
  • ab74124, at a 1/50 dilution, staining delta 1 Catenin in paraffin embedded human brain tissue by Immunohistochemistry, in the absence (left image) or presence (right image) of the immunising peptide.

References for Anti-delta 1 Catenin antibody (ab74124)

ab74124 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"