Anti-delta 1 Catenin (phospho T310) antibody [EPR2382] (ab81318)

Overview

  • Product nameAnti-delta 1 Catenin (phospho T310) antibody [EPR2382]
    See all delta 1 Catenin primary antibodies
  • Description
    Rabbit monoclonal [EPR2382] to delta 1 Catenin (phospho T310)
  • SpecificityThe antibody only detects delta 1 Catenin when phosphorylated on Threonine 310.
  • Tested applicationsSuitable for: WB, IHC-P, IPmore details
    Unsuitable for: Flow Cyt or ICC/IF
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic phosphopeptide (Human)

  • Positive control
    • 293T cell lysates treated with calyculin A Human breast carcinoma tissue
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Properties

Applications

Our Abpromise guarantee covers the use of ab81318 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 108 kDa.
IHC-P 1/100 - 1/250.
IP 1/10.
  • Application notesIs unsuitable for Flow Cyt or ICC/IF.
  • Target

    • FunctionBinds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
    • Tissue specificityExpressed in vascular endothelium.
    • Sequence similaritiesBelongs to the beta-catenin family.
      Contains 10 ARM repeats.
    • DomainA possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.
    • Post-translational
      modifications
      Phosphorylated by protein-tyrosine kinases. Dephosphorylated by PTPRJ.
    • Cellular localizationCytoplasm. Nucleus. Cell membrane. Interaction with GLIS2 promotes nuclear translocation (By similarity). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • Cadherin associated Src substrate antibody
      • Cadherin-associated Src substrate antibody
      • CAS antibody
      • Catenin (cadherin associated protein) delta 1 antibody
      • Catenin delta 1 antibody
      • Catenin delta antibody
      • Catenin delta-1 antibody
      • CTND1_HUMAN antibody
      • CTNND 1 antibody
      • CTNND antibody
      • CTNND1 antibody
      • KIAA0384 antibody
      • p120 antibody
      • P120 CAS antibody
      • p120 catenin antibody
      • P120 CTN antibody
      • p120(cas) antibody
      • p120(ctn) antibody
      • P120CAS antibody
      • P120CTN antibody
      see all

    Anti-delta 1 Catenin (phospho T310) antibody [EPR2382] images

    • All lanes : Anti-delta 1 Catenin (phospho T310) antibody [EPR2382] (ab81318) at 1/5000 dilution

      Lane 1 : 293T cell lysates untreated
      Lane 2 : 293T cell lysates treated with calyculin A

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti rabbit at 1/2000 dilution

      Predicted band size : 108 kDa
      Observed band size : 108 kDa
      Additional bands at : 120 kDa. We are unsure as to the identity of these extra bands.
    • Immunohistochemical analysis of paraffin-embedded human breast carcinoma using ab81318 at 1/100 dilution.

    References for Anti-delta 1 Catenin (phospho T310) antibody [EPR2382] (ab81318)

    ab81318 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"