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Overview

  • Product nameAnti-delta Sarcoglycan antibodySee all delta Sarcoglycan primary antibodies ...
  • Description
    Rabbit polyclonal to delta Sarcoglycan
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 37-86 (FVLLLMILIL VNLAMTIWIL KVMNFTIDGM GNLRITEKGL KLEGDSEFLQ) of Mouse delta Sarcoglycan (NP_036021).

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive controlMouse kidney cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab113813 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use a concentration of 1 µg/ml. Predicted molecular weight: 32 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionComponent of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
  • Tissue specificityMost strongly expressed in skeletal and cardiac muscle. Also detected in smooth muscle. Weak expression in brain and lung.
  • Involvement in diseaseDefects in SGCD are the cause of limb-girdle muscular dystrophy type 2F (LGMD2F) [MIM:601287]. LGMD2F is an autosomal recessive disorder.
    Defects in SGCD are the cause of cardiomyopathy dilated type 1L (CMD1L) [MIM:606685]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • Sequence similaritiesBelongs to the sarcoglycan beta/delta/gamma/zeta family.
  • Post-translational
    modifications    Glycosylated.
    Disulfide bonds are present.
  • Cellular localizationCell membrane > sarcolemma. Cytoplasm > cytoskeleton.

    • Target information above from: UniProt accession Q92629 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        35 kDa dystrophin associated glycoprotein antibody35 kDa dystrophin-associated glycoprotein antibody35DAG antibody
        CMD1L antibodyDAGD antibodyDelta-sarcoglycan antibodyDelta-SG antibodyDystrophin associated glycoprotein delta sarcoglycan antibodyLGMD2F antibodyMGC22567 antibodyPlacental delta sarcoglycan antibodySarcoglycan delta (35 kDa dystrophin associated glycoprotein) antibodySG delta antibodySGCD antibodySGCD_HUMAN antibodySGCDP antibodySGD antibody
      see all

    Anti-delta Sarcoglycan antibody images

    • Western blot - delta Sarcoglycan antibody (ab113813)
      Western blot - delta Sarcoglycan antibody (ab113813)
      Anti-delta Sarcoglycan antibody (ab113813) at 1 µg/ml + Mouse kidney lysate at 10 µg

      Predicted band size : 32 kDa

    References for Anti-delta Sarcoglycan antibody (ab113813)

    ab113813 has not yet been referenced specifically in any publications.

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