Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Sequence
      TACTPSDGPGGGAAA
    • Amino acids
      358 to 372

Associated products

Specifications

Our Abpromise guarantee covers the use of ab38193 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Lyophilised
  • Additional notes
    Used for absorption control of antiserum binding.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

  • Reconstitution
    Reconstitute with deionized water. A stock solution of 2 mg/ml is recommended for most absorption control applications.

General Info

  • Alternative names
    • D-OR-1
    • Delta type opioid receptor
    • Delta type opioid receptor DOR 1
    • Delta type opioid receptor DOR1
    • Delta-type opioid receptor
    • DOR 1
    • DOR-1
    • DOR1
    • mDOR
    • Nbor
    • Opioid receptor delta 1
    • OPRD
    • OPRD 1
    • OPRD_HUMAN
    • Oprd1
    see all
  • Relevance
    Function: G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. Tissue specificity: Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes. Similarity: Belongs to the G-protein coupled receptor 1 family. PTM: N-glycosylated. Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.
  • Cellular localization
    Multi pass membrane protein

References

ab38193 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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