Overview

  • Product name
  • Description
    Rabbit polyclonal to Deltex
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 343-587 of Human Deltex (NP_004407).

  • Positive control
    • HeLa whole cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab96439 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 67 kDa.

Target

  • Function
    Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
  • Tissue specificity
    Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Belongs to the Deltex family.
    Contains 1 RING-type zinc finger.
    Contains 2 WWE domains.
  • Domain
    The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
  • Post-translational
    modifications
    Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH.
  • Cellular localization
    Cytoplasm. Nucleus. Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear.
  • Information by UniProt
  • Database links
  • Alternative names
    • Deltex 1, E3 ubiquitin ligase antibody
    • Deltex homolog 1 (Drosophila) antibody
    • Deltex homolog 1 antibody
    • Deltex protein 1 antibody
    • Deltex-1 antibody
    • Deltex1 antibody
    • dtx1 antibody
    • DTX1_HUMAN antibody
    • E3 ubiquitin protein ligase DTX1 antibody
    • E3 ubiquitin-protein ligase DTX1 antibody
    • FXI-T1 antibody
    • Fxit 1 antibody
    • Fxit1 antibody
    • hDTX1 antibody
    • hDx 1 antibody
    • mDTX1 antibody
    • Protein deltex 1 antibody
    • Protein deltex-1 antibody
    see all

Images

  • Anti-Deltex antibody (ab96439) at 1/1000 dilution + HeLa cell lysate at 30 µg

    Predicted band size : 67 kDa

References

ab96439 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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