Overview

  • Product nameAnti-Dematin antibody
    See all Dematin primary antibodies
  • Description
    Rabbit polyclonal to Dematin
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 142-191 (KKPPIYKQRE SVGGSPQTKH LIEDLIIESS KFPAAQPPDP NQPAKIETDY) of Human Dematin (NP_001969).

  • Positive control
    • Jurkat cell lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab116391 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 46 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionActin-bundling protein. May function in mitogen-activated protein kinase pathway.
  • Tissue specificityHeart, brain, lung, skeletal muscle, and kidney.
  • Sequence similaritiesBelongs to the villin/gelsolin family.
    Contains 1 HP (headpiece) domain.
  • DomainContains at least two actin-binding sites, one in the headpiece domain and one in the amino-terminal portion.
    Consists of a large core fragment, the amino-terminal portion, and a small headpiece, the C-terminal portion. The headpiece can bind but cannot bundle actin filaments.
  • Post-translational
    modifications
    Actin-bundling activity is abolished upon phosphorylation by cAMP-dependent protein kinase.
    The N-terminus is blocked.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • DEMA antibody
    • DEMA_HUMAN antibody
    • Dematin antibody
    • DMT antibody
    • EPB49 antibody
    • erythrocyte membrane protein band 4.9 (dematin) antibody
    • Erythrocyte membrane protein band 4.9 antibody
    see all

Anti-Dematin antibody images

  • Anti-Dematin antibody (ab116391) at 1 µg/ml + Jurkat cell lysate at 10 µg

    Predicted band size : 46 kDa

References for Anti-Dematin antibody (ab116391)

ab116391 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"