Overview

  • Product nameAnti-Dematin antibody
    See all Dematin primary antibodies
  • Description
    Mouse polyclonal to Dematin
  • SpecificityReactive against mammalian transfected lysate.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Full length Human Dematin protein (AAH52805.1).

  • Positive control
    • Rat brain cytoplasmic lysate Transfected 293T cytoplasmic lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab89161 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 46 kDa.

Target

  • FunctionActin-bundling protein. May function in mitogen-activated protein kinase pathway.
  • Tissue specificityHeart, brain, lung, skeletal muscle, and kidney.
  • Sequence similaritiesBelongs to the villin/gelsolin family.
    Contains 1 HP (headpiece) domain.
  • DomainContains at least two actin-binding sites, one in the headpiece domain and one in the amino-terminal portion.
    Consists of a large core fragment, the amino-terminal portion, and a small headpiece, the C-terminal portion. The headpiece can bind but cannot bundle actin filaments.
  • Post-translational
    modifications
    Actin-bundling activity is abolished upon phosphorylation by cAMP-dependent protein kinase.
    The N-terminus is blocked.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • DEMA antibody
    • DEMA_HUMAN antibody
    • Dematin antibody
    • DMT antibody
    • EPB49 antibody
    • erythrocyte membrane protein band 4.9 (dematin) antibody
    • Erythrocyte membrane protein band 4.9 antibody
    see all

Anti-Dematin antibody images

  • Anti-Dematin antibody (ab89161) at 1 µg/ml + Rat brain tissue lysate at 50 µg

    Predicted band size : 46 kDa
  • All lanes : Anti-Dematin antibody (ab89161) at 1 µg/ml

    Lane 1 : Dematin transfected 293T cell lysate
    Lane 2 : Non transfected cell 293T lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 46 kDa

References for Anti-Dematin antibody (ab89161)

This product has been referenced in:
  • Ryu MS  et al. Proteomic analysis shows the upregulation of erythrocyte dematin in zinc-restricted human subjects. Am J Clin Nutr 95:1096-102 (2012). Human . Read more (PubMed: 22456662) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"