The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Detects a band of approximately 77 kDa.
FunctionPart of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.
Tissue specificityUbiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.
Sequence similaritiesBelongs to the nucleosome assembly protein (NAP) family.
Post-translational modificationsPhosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation.
Cellular localizationNucleus. Cytoplasm. Enriched in transcriptionally active regions of chromatin in neurons.