Overview

  • Product name
  • Description
    Goat polyclonal to DENTT
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Dog, Cynomolgus monkey
  • Immunogen

    Synthetic peptide:

    C-PNGWANPGKRGKTG

    with a Cysteine residue linker, corresponding to C terminal amino acids 680-693 of Human DENTT (NP_071400.1).

  • Positive control
    • Human testis tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab126290 is purified from Goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab126290 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 - 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/1. Predicted molecular weight: 79 kDa. Preliminary experiments in Human Testis lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml).

Target

  • Function
    Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.
  • Tissue specificity
    Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.
  • Sequence similarities
    Belongs to the nucleosome assembly protein (NAP) family.
  • Post-translational
    modifications
    Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation.
  • Cellular localization
    Nucleus. Cytoplasm. Enriched in transcriptionally active regions of chromatin in neurons.
  • Information by UniProt
  • Database links
  • Alternative names
    • CASK interacting nucleosome assembly protein antibody
    • CDA1 antibody
    • Cell division autoantigen 1 antibody
    • CINAP antibody
    • CTCL antibody
    • CTCL tumor antigen se20 4 antibody
    • CTCL-associated antigen se20-4 antibody
    • Cutaneous T cell lymphoma associated antigen se20 4 antibody
    • Cutaneous T cell lymphoma associated tumor antigen se20 4 antibody
    • Cutaneous T-cell lymphoma-associated antigen se20-4 antibody
    • Differentially Expressed Nucleolar TGF beta1 Target antibody
    • Differentially Expressed Nucleolar TGF beta1 Target protein antibody
    • Differentially-expressed nucleolar TGF-beta1 target protein antibody
    • HRIHFB2216 antibody
    • NP79 antibody
    • Nuclear protein of 79 kDa antibody
    • RP1 290F12.2 antibody
    • SE20 4 antibody
    • SE204 antibody
    • Testis specific protein Y encoded like 2 antibody
    • testis-specific protein Y encoded-like 2 antibody
    • Testis-specific Y-encoded-like protein 2 antibody
    • TSPX antibody
    • TSPY like 2 antibody
    • TSPY like protein 2 antibody
    • TSPY-like protein 2 antibody
    • TSPYL2 antibody
    • TSYL2_HUMAN antibody
    see all

Images

  • ab126290, at 5 ug/ml, staining DENTT in paraffin-embedded Human testis tissue by Immunohistochemistry.

References

ab126290 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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