Overview

  • Product name
  • Description
    Rabbit polyclonal to DEP1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human DEP1 protein with a His tag

  • Positive control
    • K562 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab107116 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/100. Predicted molecular weight: 146 kDa.

Target

  • Function
    Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.
  • Tissue specificity
    Expressed in the promyelocytic cell line HL60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, and the interleukin-3 and erythropoietin-dependent leukemic cell line F-36E. Expressed predominantly in epithelial cells and lymphocytes. Enhanced expression at high cell density.
  • Sequence similarities
    Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
    Contains 9 fibronectin type-III domains.
    Contains 1 tyrosine-protein phosphatase domain.
  • Post-translational
    modifications
    N- and O-glycosylated.
  • Cellular localization
    Cell membrane. Cell projection > ruffle membrane. Cell junction. After T cell stimulation, it is temporarily excluded from immunological synapses.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD 148 antibody
    • CD148 antibody
    • CD148 antigen antibody
    • Density enhanced phosphatase 1 antibody
    • Density-enhanced phosphatase 1 antibody
    • DEP 1 antibody
    • DEP-1 antibody
    • HPTP eta antibody
    • HPTPeta antibody
    • Human density enhanced phosphatase 1 antibody
    • Protein tyrosine phosphatase eta antibody
    • Protein tyrosine phosphatase receptor type J antibody
    • Protein tyrosine phosphatase receptor type J polypeptide antibody
    • Protein-tyrosine phosphatase eta antibody
    • Protein-tyrosine phosphatase receptor type J antibody
    • PTPJ antibody
    • Ptprj antibody
    • PTPRJ_HUMAN antibody
    • R PTP Eta antibody
    • R-PTP-eta antibody
    • R-PTP-J antibody
    • Receptor type tyrosine protein phosphatase eta antibody
    • Receptor-type tyrosine-protein phosphatase eta antibody
    • SCC 1 antibody
    • SCC1 antibody
    • susceptibility to colon cancer 1, mouse, homolog of antibody
    see all

Images

  • Anti-DEP1 antibody (ab107116) at 1/50 dilution + K562 cell lysate at 35 µg

    Predicted band size : 146 kDa

References

ab107116 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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