Overview

  • Product name
    Dequalinium chloride
  • Description
    PKC inhibitor. Selective apamin-sensitive K+ channel blocker.
  • Biological description
    PKC inhibitor (IC50 = 7-18 μM). Selective apamin-sensitive K+ channel blocker (IC50 = 1.1 μM). Selectively accumulates in carcinoma cell mitochondria. Shows antimicrobial effects in vivo.
  • Purity
    > 99%

Properties

  • Chemical name
    1-[10-(4-Amino-2-methylquinolin-1-ium-1-yl)decyl]-2-methylquinolin-1-ium-4-amine dichloride
  • Molecular weight
    527.57
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C30H40Cl2N4
  • CAS Number
    522-51-0
  • PubChem identifier
    10649
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC1=[N+](C2=CC=CC=C2C(=C1)N)CCCCCCCCCC[N+]3=C(C=C(C4=CC=CC=C43)N)C.[Cl-].[Cl-]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Hassan KA  et al. Homologs of the Acinetobacter baumannii AceI transporter represent a new family of bacterial multidrug efflux systems. MBio 6: (2015). Read more (PubMed: 25670776) »
  • Della Casa V  et al. Antimicrobial activity of dequalinium chloride against leading germs of vaginal infections. Arzneimittelforschung 52:699-705 (2002). Read more (PubMed: 12404886) »
  • Rotenberg SA & Sun XG Photoinduced inactivation of protein kinase C by dequalinium identifies the RACK-1-binding domain as a recognition site. J Biol Chem 273:2390-5 (1998). Read more (PubMed: 9442087) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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