Overview

  • Product name
  • Description
    Rabbit polyclonal to DERL2
  • Specificity
    This antibody reacts specifically with human 27 kDa DERL2 protein.
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide derived from the C-terminal domain of (Human) DERL2 protein.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: Whole serum
  • Purity
    Whole antiserum
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab71552 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
WB 1/200 - 1/2000. Predicted molecular weight: 27 kDa.

Target

  • Function
    Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.
  • Tissue specificity
    Ubiquitous. Overexpressed in various hepatocarcinomas.
  • Sequence similarities
    Belongs to the derlin family.
  • Cellular localization
    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Carcinoma related antibody
    • CGI 101 antibody
    • Degradation in endoplasmic reticulum protein 2 antibody
    • DER 2 antibody
    • Der1 like domain family member 2 antibody
    • Der1-like protein 2 antibody
    • DER2 antibody
    • DERL 2 antibody
    • DERL2 antibody
    • DERL2_HUMAN antibody
    • Derlin 2 antibody
    • Derlin-2 antibody
    • Derlin2 antibody
    • DERtrin 2 antibody
    • DERtrin-2 antibody
    • DERtrin2 antibody
    • F LAN 1 antibody
    • F LANa antibody
    • F-LAN-1 antibody
    • F-LANa antibody
    • FLANa antibody
    see all

References

ab71552 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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