Overview

  • Product nameAnti-DERL3 antibody
    See all DERL3 primary antibodies
  • Description
    Rabbit polyclonal to DERL3
  • Tested applicationsSuitable for: WB, IP, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Cow
  • Immunogen

    Synthetic peptide:

    QPGGKRLLQTPGFL

    conjugated to KLH, corresponding to amino acids 192-205 of Human DERL3

  • Positive control
    • Whole extract of HEK-293T cells expressing recombinant human DERL3 and human HeLa cells.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 15mM Sodium Azide
    Constituents: 0.01M PBS, pH 7.4
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab69812 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IP
ICC/IF
  • Application notesICC/IF: Use at a concentration of 10 - 20 µg/ml.
    IP: Use at a concentration of 5 - 10 µg.
    WB: Use at a concentration of 2 - 5 µg/ml. Predicted molecular weight: 27 kDa.
    Detection of the band by immunoblotting is specifically inhibited by the immunizing peptide.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionFunctional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate.
    • Tissue specificityUnlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine.
    • Sequence similaritiesBelongs to the derlin family.
    • Cellular localizationEndoplasmic reticulum membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • C22orf14 antibody
      • Degradation in endoplasmic reticulum protein 3 antibody
      • DER 3 antibody
      • Der1 like domain family member 3 antibody
      • Der1 like protein 3 antibody
      • Der1-like protein 3 antibody
      • DER3 antibody
      • DERL 3 antibody
      • Derl3 antibody
      • DERL3_HUMAN antibody
      • Derlin 3 antibody
      • Derlin 3 protein antibody
      • Derlin-3 antibody
      • Derlin3 antibody
      • DERtrin 3 antibody
      • DERtrin-3 antibody
      • DERtrin3 antibody
      • IZP 6 antibody
      • IZP6 antibody
      • LLN 2 antibody
      • LLN2 antibody
      • MGC71803 antibody
      see all

    References for Anti-DERL3 antibody (ab69812)

    ab69812 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab69812.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"