Overview

  • Product name
  • Description
    Rabbit polyclonal to DERL3
  • Tested applications
    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to N-terminal residues of Human DERL3

  • Positive control
    • Pancreatic tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.01% Sodium Azide
    Constituents: 50% Glycerol, PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab78233 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 27 kDa.
ELISA Use a concentration of 1 µg/ml.
IHC-P Use a concentration of 20 µg/ml.

Target

  • Function
    Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate.
  • Tissue specificity
    Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine.
  • Sequence similarities
    Belongs to the derlin family.
  • Cellular localization
    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • C22orf14 antibody
    • Degradation in endoplasmic reticulum protein 3 antibody
    • DER 3 antibody
    • Der1 like domain family member 3 antibody
    • Der1 like protein 3 antibody
    • Der1-like protein 3 antibody
    • DER3 antibody
    • DERL 3 antibody
    • Derl3 antibody
    • DERL3_HUMAN antibody
    • Derlin 3 antibody
    • Derlin 3 protein antibody
    • Derlin-3 antibody
    • Derlin3 antibody
    • DERtrin 3 antibody
    • DERtrin-3 antibody
    • DERtrin3 antibody
    • IZP 6 antibody
    • IZP6 antibody
    • LLN 2 antibody
    • LLN2 antibody
    • MGC71803 antibody
    see all

Images

  • Immunohistochemistry analysis of formalin-fixed, paraffin embedded Human pancreas tissue using ab78233 at 20µg/ml.

References

This product has been referenced in:
  • Lopez-Serra P  et al. A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect. Nat Commun 5:3608 (2014). WB . Read more (PubMed: 24699711) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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