Overview

  • Product name
    Anti-Dermatopontin antibody
    See all Dermatopontin primary antibodies
  • Description
    Rabbit polyclonal to Dermatopontin
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 52-80 of Human Dermatopontin (NP_001928.2).

  • Positive control
    • Dermatopontin-transfected 293 cell line lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Ammonium Sulphate Precipitation
  • Purification notes
    ab112600 is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab112600 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/100. Predicted molecular weight: 24 kDa.

Target

  • Function
    Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation.
  • Tissue specificity
    Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.
  • Sequence similarities
    Belongs to the dermatopontin family.
  • Post-translational
    modifications
    Sulfated on tyrosine residue(s).
  • Cellular localization
    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • DERM_HUMAN antibody
    • Dermatopontin antibody
    • Dpt antibody
    • TRAMP antibody
    • Tyrosine rich acidic matrix protein antibody
    • Tyrosine-rich acidic matrix protein antibody
    see all

Images

  • All lanes : Anti-Dermatopontin antibody (ab112600) at 1/50 dilution

    Lane 1 : 293 cell line lysates
    Lane 2 : 293 cell line lysates, transiently transfected with the Dermatopontin gene

    Lysates/proteins at 2 µg per lane.


    Predicted band size : 24 kDa

References

ab112600 has not yet been referenced specifically in any publications.

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There are currently no Customer reviews or Questions for ab112600.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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