Overview

  • Product name
    Anti-Dermatopontin antibody
    See all Dermatopontin primary antibodies
  • Description
    Rabbit polyclonal to Dermatopontin
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Human, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 45-94 (GFSYQCPHGQ VVVAVRSIFS KKEGSDRQWN YACMPTPQSL GEPTECWWEE) of Mouse Dermatopontin (NP_062733).

  • Positive control
    • Mouse pancreas lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab118710 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 24 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation.
  • Tissue specificity
    Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.
  • Sequence similarities
    Belongs to the dermatopontin family.
  • Post-translational
    modifications
    Sulfated on tyrosine residue(s).
  • Cellular localization
    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • DERM_HUMAN antibody
    • Dermatopontin antibody
    • Dpt antibody
    • TRAMP antibody
    • Tyrosine rich acidic matrix protein antibody
    • Tyrosine-rich acidic matrix protein antibody
    see all

Images

  • Anti-Dermatopontin antibody (ab118710) at 1 µg/ml + Mouse pancreas lysate at 10 µg

    Secondary
    Goat anti-Rabbit IgG-HRP

    Predicted band size : 24 kDa

References

ab118710 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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