• Product nameAnti-Desmin antibody
    See all Desmin primary antibodies
  • Description
    Rabbit polyclonal to Desmin
  • Specificityab64969 detects endogenous levels of total Desmin protein.
  • Tested applicationsSuitable for: ELISA, IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic non-phosphopeptide derived from human Desmin around the phosphorylation site of serine 60 (R-T-SP-G-G).

  • Positive control
    • human colon carcinoma tissue, extracts from HeLa cells and HepG2 cells.



Our Abpromise guarantee covers the use of ab64969 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesELISA: 1/20000.
    IHC-P: 1/50 - 1/100.
    WB: 1/500 - 1/1000. Detects a band of approximately 60 kDa (predicted molecular weight: 52 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionDesmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.
    • Involvement in diseaseDefects in DES are the cause of myopathy myofibrillar desmin-related (MFM-DES) [MIM:601419]; also known as desmin-related myopathy (DRM). A neuromuscular disorder characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by myofibrillar destruction with intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells.
      Defects in DES are the cause of cardiomyopathy dilated type 1I (CMD1I) [MIM:604765]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
      Defects in DES are the cause of neurogenic scapuloperoneal syndrome Kaeser type (Kaeser syndrome) [MIM:181400]. Kaeser syndrome is an autosomal dominant disorder with a peculiar scapuloperoneal distribution of weakness and atrophy. A large clinical variability is observed ranging from scapuloperoneal, limb grindle and distal phenotypes with variable cardiac or respiratory involvement. Facial weakness, dysphagia and gynaecomastia are frequent additional symptoms. Affected men seemingly bear a higher risk of sudden, cardiac death as compared to affected women. Histological and immunohistochemical examination of muscle biopsy specimens reveal a wide spectrum of findings ranging from near normal or unspecific pathology to typical, myofibrillar changes with accumulation of desmin.
    • Sequence similaritiesBelongs to the intermediate filament family.
    • Cellular localizationCytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • CMD1I antibody
      • CSM1 antibody
      • CSM2 antibody
      • DES antibody
      • DESM_HUMAN antibody
      • Desmin antibody
      • FLJ12025 antibody
      • FLJ39719 antibody
      • FLJ41013 antibody
      • FLJ41793 antibody
      • Intermediate filament protein antibody
      • OTTHUMP00000064865 antibody
      see all

    Anti-Desmin antibody images

    • All lanes : Anti-Desmin antibody (ab64969) at 1/500 dilution

      Lane 1 : HeLa cell extract; without immunizing peptide
      Lane 2 : HepG2 cell extract; without immunizing peptide
      Lane 3 : HepG2 cell extract; with immunizing peptide

      Predicted band size : 52 kDa
      Observed band size : 60 kDa (why is the actual band size different from the predicted?)
    • Immunohistochemical staining of Desmin in paraffin embedded human colon carcinoma tissue using ab64969 at a dilution of 1/50; in the presence and absence of the immunizing peptide.

    References for Anti-Desmin antibody (ab64969)

    ab64969 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab64969.
    Please use the links above to contact us or submit feedback about this product.