• Product nameAnti-Desmin antibody
    See all Desmin primary antibodies
  • Description
    Goat polyclonal to Desmin
  • Tested applicationsSuitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human, Pig
    Predicted to work with: Chicken, Hamster, Cow, Dog
  • Immunogen

    Synthetic peptide:


    , corresponding to C terminal amino acids 454 - 468 of Human Desmin (NP_001918.3)

  • Positive control
    • Human skeletal muscle lysate Human prostate



Our Abpromise guarantee covers the use of ab80503 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3 - 6 µg/ml.
WB Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 54 kDa.


  • FunctionDesmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.
  • Involvement in diseaseDefects in DES are the cause of myopathy myofibrillar desmin-related (MFM-DES) [MIM:601419]; also known as desmin-related myopathy (DRM). A neuromuscular disorder characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by myofibrillar destruction with intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells.
    Defects in DES are the cause of cardiomyopathy dilated type 1I (CMD1I) [MIM:604765]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in DES are the cause of neurogenic scapuloperoneal syndrome Kaeser type (Kaeser syndrome) [MIM:181400]. Kaeser syndrome is an autosomal dominant disorder with a peculiar scapuloperoneal distribution of weakness and atrophy. A large clinical variability is observed ranging from scapuloperoneal, limb grindle and distal phenotypes with variable cardiac or respiratory involvement. Facial weakness, dysphagia and gynaecomastia are frequent additional symptoms. Affected men seemingly bear a higher risk of sudden, cardiac death as compared to affected women. Histological and immunohistochemical examination of muscle biopsy specimens reveal a wide spectrum of findings ranging from near normal or unspecific pathology to typical, myofibrillar changes with accumulation of desmin.
  • Sequence similaritiesBelongs to the intermediate filament family.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • CMD1I antibody
    • CSM1 antibody
    • CSM2 antibody
    • DES antibody
    • DESM_HUMAN antibody
    • Desmin antibody
    • FLJ12025 antibody
    • FLJ39719 antibody
    • FLJ41013 antibody
    • FLJ41793 antibody
    • Intermediate filament protein antibody
    • OTTHUMP00000064865 antibody
    see all

Anti-Desmin antibody images

  • All lanes : Anti-Desmin antibody (ab80503) at 0.5 µg/ml

    Lane 1 : Pig Skeletal Muscle lysate
    Lane 2 : Mouse Skeletal Muscle lysate
    Lane 3 : Rat Skeletal Muscle lysate

    Lysates/proteins at 35 µg per lane.

    Predicted band size : 54 kDa
    Observed band size : 54 kDa
  • Anti-Desmin antibody (ab80503) at 0.2 µg/ml + human skeletal muscle lysate at 35 µg

    Predicted band size : 54 kDa
    Observed band size : 54 kDa
  • ab80503 at 3.8 µg/ml staining Desmin in Human prostate tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

References for Anti-Desmin antibody (ab80503)

This product has been referenced in:
  • Zhao X  et al. Spontaneous immortalization of mouse liver sinusoidal endothelial cells. Int J Mol Med 35:617-24 (2015). ICC/IF ; Mouse . Read more (PubMed: 25585915) »

See 1 Publication for this product

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