Overview

  • Product nameAnti-Desmocollin 2 antibody
    See all Desmocollin 2 primary antibodies
  • Description
    Mouse polyclonal to Desmocollin 2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length human Desmocollin 2 protein (Isoform 2B; NP_004940.1).

  • Positive control
    • Desmocollin 2 transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab72792 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 93 kDa.

Target

  • FunctionComponent of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
  • Tissue specificityExpressed in epithelia, myocardium and lymph nodes.
  • Involvement in diseaseDefects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia type 11 (ARVD11) [MIM:610476]; also known as arrhythmogenic right ventricular cardiomyopathy 11 (ARVC11). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
  • Sequence similaritiesContains 5 cadherin domains.
  • DomainCalcium may be bound by the cadherin-like repeats.
  • Cellular localizationCell membrane. Cell junction > desmosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • ARVD11 antibody
    • Cadherin family member 2 antibody
    • CDHF2 antibody
    • Desmocollin 3 antibody
    • Desmocollin-2 antibody
    • Desmocollin-3 antibody
    • Desmocollin2 antibody
    • Desmosomal glycoprotein II and III antibody
    • Desmosomal glycoprotein II antibody
    • Desmosomal glycoprotein II/III antibody
    • Desmosomal glycoprotein III antibody
    • DG2 antibody
    • DGII/III antibody
    • DKFZp686I11137 antibody
    • DSC 2 antibody
    • DSC2 antibody
    • DSC2_HUMAN antibody
    • DSC3 antibody
    see all

Anti-Desmocollin 2 antibody images

  • All lanes : Anti-Desmocollin 2 antibody (ab72792) at 1/500 dilution

    Lane 1 : Desmocollin 2 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 93 kDa
    Observed band size : 130 kDa (why is the actual band size different from the predicted?)

References for Anti-Desmocollin 2 antibody (ab72792)

This product has been referenced in:
  • Lowndes M  et al. Different roles of cadherins in the assembly and structural integrity of the desmosome complex. J Cell Sci 127:2339-50 (2014). Read more (PubMed: 24610950) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"