Overview

  • Product nameAnti-Desmocollin 2 antibody
    See all Desmocollin 2 primary antibodies
  • Description
    Mouse monoclonal to Desmocollin 2
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Human, Chimpanzee, Rhesus monkey
  • Immunogen

    Recombinant fragment: SREASPRSAM STATVTVNVE DQDEGPECNP PIQTVRMKEN AEVGTTSNGY KAYDPETRSS SGIRYKKLTD PTGWVTIDEN TGSIKVFRSL D, corresponding to amino acids 444-535 of Human Desmocollin 2 (NP_077740) with tag.

  • Positive control
    • Recombinant tagged human Desmocollin 2 fragment.

Properties

Applications

Our Abpromise guarantee covers the use of ab76628 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesELISA: Use at an assay dependent dilution.
    WB: Use at a concentration of 1 - 5 µg/ml. Predicted molecular weight: 100 kDa.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionComponent of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
    • Tissue specificityExpressed in epithelia, myocardium and lymph nodes.
    • Involvement in diseaseDefects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia type 11 (ARVD11) [MIM:610476]; also known as arrhythmogenic right ventricular cardiomyopathy 11 (ARVC11). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
    • Sequence similaritiesContains 5 cadherin domains.
    • DomainCalcium may be bound by the cadherin-like repeats.
    • Cellular localizationCell membrane. Cell junction > desmosome.
    • Information by UniProt
    • Database links
    • Alternative names
      • ARVD11 antibody
      • Cadherin family member 2 antibody
      • CDHF2 antibody
      • Desmocollin 3 antibody
      • Desmocollin-2 antibody
      • Desmocollin-3 antibody
      • Desmocollin2 antibody
      • Desmosomal glycoprotein II and III antibody
      • Desmosomal glycoprotein II antibody
      • Desmosomal glycoprotein II/III antibody
      • Desmosomal glycoprotein III antibody
      • DG2 antibody
      • DGII/III antibody
      • DKFZp686I11137 antibody
      • DSC 2 antibody
      • DSC2 antibody
      • DSC2_HUMAN antibody
      • DSC3 antibody
      see all

    Anti-Desmocollin 2 antibody images

    • Anti-Desmocollin 2 antibody (ab76628) at 1 µg/ml + Recombinant tagged human Desmocollin 2 fragment at 0.2 µg

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP at 1/5000 dilution

      Predicted band size : 100 kDa
      Observed band size : 37 kDa (why is the actual band size different from the predicted?)

    References for Anti-Desmocollin 2 antibody (ab76628)

    ab76628 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab76628.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"