Anti-Desmoglein 1 antibody (ab122913)

Overview

  • Product name
    Anti-Desmoglein 1 antibody
    See all Desmoglein 1 primary antibodies
  • Description
    Goat polyclonal to Desmoglein 1
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to internal sequence amino acids of Human Desmoglein 1.

  • Positive control
    • Human Skin tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab122913 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3.75 µg/ml.

Target

  • Function
    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
  • Tissue specificity
    Epidermis, tongue, tonsil and esophagus.
  • Involvement in disease
    Defects in DSG1 are the cause of palmoplantar keratoderma striate type 1 (SPPK1) [MIM:148700]; also known as keratosis palmoplantaris striata I. SPPK1 is a dermatoligical disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger.
  • Sequence similarities
    Contains 4 cadherin domains.
  • Domain
    Calcium may be bound by the cadherin-like repeats.
  • Cellular localization
    Cell membrane. Cell junction > desmosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cadherin family member 4 antibody
    • CDHF4 antibody
    • Desmoglein-1 antibody
    • Desmosomal glycoprotein 1 antibody
    • DG1 antibody
    • DGI antibody
    • DSG antibody
    • DSG1 antibody
    • DSG1_HUMAN antibody
    • EPKHE antibody
    • EPKHIA antibody
    • Pemphigus foliaceus antigen antibody
    • PPKS1 antibody
    • SPPK1 antibody
    see all

Images

  • ab122913, at 3.75 µg/ml, staining Desmoglein 1 in Formalin-fixed, Paraffin-embedded Human Skin tissue by Immunohistochemistry.

References

ab122913 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Merci beaucoup pour votre requete. Veuillez trouver les MSDS en document attaché. Comme ces deux anticorps contiennent de l'azide, ces fiches sont relatives à ceci. Pour ces anticorps, ces fiches MSDS peuvent aussi etre directement téléchargées de la f...

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