Anti-Desmoglein 2 antibody [EPR6767(B)] (ab124683)


  • Product nameAnti-Desmoglein 2 antibody [EPR6767(B)]
    See all Desmoglein 2 primary antibodies
  • Description
    Rabbit monoclonal [EPR6767(B)] to Desmoglein 2
  • Tested applicationsSuitable for: WB, IP, Flow Cytmore details
    Unsuitable for: ICC or IHC-P
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A synthetic peptide, corresponding to residues in the extracellular domain of Human Desmoglein 2.

  • Positive control
    • SKBR3, HepG2, 293T, A431, HeLa and T47D cell lysates; T47D cells.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.



Our Abpromise guarantee covers the use of ab124683 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50000 - 1/200000. Detects a band of approximately 160 kDa (predicted molecular weight: 122 kDa).
IP 1/10 - 1/100.
Flow Cyt 1/10 - 1/100. ab172730-Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
  • Application notesIs unsuitable for ICC or IHC-P.
  • Target

    • FunctionComponent of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
    • Tissue specificityAll of the tissues tested and carcinomas.
    • Involvement in diseaseDefects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10) [MIM:610193]; also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
      Genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB) [MIM:612877]. A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    • Sequence similaritiesContains 4 cadherin domains.
    • DomainCalcium may be bound by the cadherin-like repeats.
    • Cellular localizationCell membrane. Cell junction > desmosome.
    • Information by UniProt
    • Database links
    • Alternative names
      • ARVC 10 antibody
      • ARVC10 antibody
      • ARVD 10 antibody
      • ARVD10 antibody
      • Cadherin family member 5 antibody
      • CDHF 5 antibody
      • CDHF5 antibody
      • CMD1BB antibody
      • Desmoglein 2 antibody
      • Desmoglein-2 antibody
      • Desmoglein2 antibody
      • DSG 2 antibody
      • DSG2 antibody
      • DSG2_HUMAN antibody
      • HDGC antibody
      • HDGC included antibody
      • Human Desmoglein colon antibody
      • MGC117034 antibody
      • MGC117036 antibody
      • MGC117037 antibody
      see all

    Anti-Desmoglein 2 antibody [EPR6767(B)] images

    • All lanes : Anti-Desmoglein 2 antibody [EPR6767(B)] (ab124683) at 1/50000 dilution

      Lane 1 : SKBR3 cell lysate
      Lane 2 : HepG2 cell lysate
      Lane 3 : 293T cell lysate
      Lane 4 : A431 cell lysate
      Lane 5 : HeLa cell lysate
      Lane 6 : T47D cell lysate

      Lysates/proteins at 10 µg per lane.

      Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size : 122 kDa
    • ab124683 at 1/10 dilution staining Desmoglein 2 in T47D cells by Flow Cytometry (red). Rabbit IgG negative control (green).
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    References for Anti-Desmoglein 2 antibody [EPR6767(B)] (ab124683)

    This product has been referenced in:
    • Kamekura R  et al. Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier. Mol Biol Cell 26:3165-77 (2015). Read more (PubMed: 26224314) »

    See 1 Publication for this product

    Product Wall

    Application Immunoprecipitation
    Immuno-precipitation step Protein A/G
    Sample Mouse Cell lysate - whole cell (Hl-1 (murine cardiac muscel cell line))
    Specification Hl-1 (murine cardiac muscel cell line)
    Total protein in input 500 µg

    Abcam user community

    Verified customer

    Submitted Dec 31 2013

    I am very pleased to hear you would like to accept our offer and test ab124683 in ICC/IF. This code will give you 1 free primary antibodybefore the expiration date. To redeem this offer, please submit an Abreview for ICC/IF and include this code in the...

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