• Product name
    Anti-Desmoglein 2 antibody - N-terminal
    See all Desmoglein 2 primary antibodies
  • Description
    Rabbit polyclonal to Desmoglein 2 - N-terminal
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (Human) conjugated to KLH, from the N-terminal region of human Desmoglein 2.

  • Positive control
    • T47D cell line lysate



Our Abpromise guarantee covers the use of ab76668 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50 - 1/100. Detects a band of approximately 122 kDa (predicted molecular weight: 122 kDa).
ELISA 1/1000.


  • Function
    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
  • Tissue specificity
    All of the tissues tested and carcinomas.
  • Involvement in disease
    Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10) [MIM:610193]; also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
    Genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB) [MIM:612877]. A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • Sequence similarities
    Contains 4 cadherin domains.
  • Domain
    Calcium may be bound by the cadherin-like repeats.
  • Cellular localization
    Cell membrane. Cell junction > desmosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • ARVC 10 antibody
    • ARVC10 antibody
    • ARVD 10 antibody
    • ARVD10 antibody
    • Cadherin family member 5 antibody
    • CDHF 5 antibody
    • CDHF5 antibody
    • CMD1BB antibody
    • Desmoglein 2 antibody
    • Desmoglein-2 antibody
    • Desmoglein2 antibody
    • DSG 2 antibody
    • DSG2 antibody
    • DSG2_HUMAN antibody
    • HDGC antibody
    • HDGC included antibody
    • Human Desmoglein colon antibody
    • MGC117034 antibody
    • MGC117036 antibody
    • MGC117037 antibody
    see all

Anti-Desmoglein 2 antibody - N-terminal images

  • Anti-Desmoglein 2 antibody - N-terminal (ab76668) at 1/50 dilution + T47D cell lysate at 35 µg

    Predicted band size : 122 kDa
    Observed band size : 122 kDa

References for Anti-Desmoglein 2 antibody - N-terminal (ab76668)

This product has been referenced in:
  • Resnik N  et al. Desmosome assembly and cell-cell adhesion are membrane raft-dependent processes. J Biol Chem 286:1499-507 (2011). WB ; Dog . Read more (PubMed: 21071449) »
  • Lokar M  et al. Protruding membrane nanotubes: attachment of tubular protrusions to adjacent cells by several anchoring junctions. Protoplasma 246:81-7 (2010). ICC/IF ; Human . Read more (PubMed: 20526853) »

See all 2 Publications for this product

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