Overview

  • Product nameAnti-Desmoglein 4 antibody
    See all Desmoglein 4 primary antibodies
  • Description
    Rabbit polyclonal to Desmoglein 4
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to C terminal residues of human DSG4.

Properties

Applications

Our Abpromise guarantee covers the use of ab54547 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 114 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA Use at an assay dependent dilution.

Target

  • RelevanceDSG4(Desmoglein 4) is a component of intercellular desmosome junctions. DSG4 is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. DSG4 coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. The essential role of desmoglein 4 in skin was established by identifying mutations in families with inherited hypotrichosis, as well as in the lanceolate hair mouse. The human desmoglein 4 gene (DSG4) demonstrates that it is composed of 16 exons spanning approximately 37 kb of 18q12 and is situated between DSG1 and DSG3. Defects in DSG4 are the cause of localized autosomal hypotrichosis (LAH). LAH is an autosomal recessive skin disorder. DSG4 is one of the target molecules recognized by autoantibodies in patients with pemphigus vulgaris. Pemphigus vulgaris is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion.
  • Cellular localizationCell membrane; single pass type I membrane protein.
  • Database links
  • Alternative names
    • CDGF 13 antibody
    • CDGF13 antibody
    • CDH family member 13 antibody
    • CDHF 13 antibody
    • CDHF13 antibody
    • Desmoglein 4 antibody
    • Desmoglein4 antibody
    • DSG 4 antibody
    • DSG4 antibody
    • LAH antibody
    see all

References for Anti-Desmoglein 4 antibody (ab54547)

ab54547 has not yet been referenced specifically in any publications.

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