Overview

  • Product name
    Desvenlafaxine
  • Description
    Potent SERT and NET inhibitor
  • Biological description
    Potent SERT and NET inhibitor (Ki values are 40.2 and 558.4 nM respectively). Desvenlafaxine succinate (ab143602) precursor. Venlafaxine (ab120715) derivative. Shows antidepressant effects in vivo. Orally active.
  • Purity
    > 99%

Properties

  • Chemical name
    4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol
  • Molecular weight
    263.38
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C16H25NO2
  • CAS Number
    93413-62-8
  • PubChem identifier
    125017
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in ethanol to 10 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Kumari A  et al. Prenatal desvenlafaxine induced behavioural alterations in Swiss albino mice. Ann Neurosci 21:19-21 (2014). Read more (PubMed: 25206049) »
  • Song J  et al. Acute and chronic effects of desvenlafaxine on gastrointestinal transit and motility in dogs. Neurogastroenterol Motil 25:824-e637 (2013). Read more (PubMed: 23865827) »
  • Bachmeier CJ  et al. Induction of drug efflux protein expression by venlafaxine but not desvenlafaxine. Biopharm Drug Dispos 32:233-44 (2011). Read more (PubMed: 21446053) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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