Overview

  • Product name
    Anti-Dexamethasone antibody
  • Description
    Rabbit polyclonal to Dexamethasone
  • Specificity
    Cross reactivity: Dexamethasone 100%, Dexamethasone-21-Phosphate <0.01%, Dexamethasone-21-Ac 29%, Beta-Methasone 0.1%, Testosterone <0.01%.
  • Tested applications
    Suitable for: ELISA, Flow Cyt, ICC/IF, IHC-Frmore details
  • Immunogen

    Chemical/ Small Molecule: Dexamethasone conjugated to BSA.

  • Positive control
    • Dexamethasone-thyroglobulin (2µg/ml) conjugate can be used for plate coating.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • Purification notes
    This antibody was purified by ammonium sulphate fractionation.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab35000 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000 - 1/4000.
Flow Cyt Use at an assay dependent concentration. PubMed: 22643864ab171870-Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
ICC/IF Use at an assay dependent concentration. PubMed: 22643864
IHC-Fr Use at an assay dependent concentration. PubMed: 23663237

Target

  • Relevance
    Dexamethasone is potent glucocorticoid anti-inflammatory agent which regulates T-cell survival, growth and differentiation. It is known by various trivial and systematic names including 9-alpha fluoro 16-alpha methylprednisolone. Dexamethasone is also used as an inducer of gene expression using a dexamethasone-inducible promoter system. In horse racing Dexamethasone is one of many steroids drugs which are prohibited but is commonly used in racing stables as a treatment for respiratory complaints.

References

This product has been referenced in:
  • Grewal AS  et al. Dexamethasone uptake in the murine organ of Corti with transtympanic versus systemic administration. J Otolaryngol Head Neck Surg 42:19 (2013). IHC-Fr . Read more (PubMed: 23663237) »
  • Graversen JH  et al. Targeting the Hemoglobin Scavenger receptor CD163 in Macrophages Highly Increases the Anti-inflammatory Potency of Dexamethasone. Mol Ther : (2012). ICC/IF, Flow Cyt . Read more (PubMed: 22643864) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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